No association between pyrite content and lung cell responses to coal particles
نویسندگان
چکیده
Abstract There has been an increase in the identification of cases coal workers’ pneumoconiosis (CWP) recent years around world. While there are a range possible explanations for this, studies have implicated pyrite content as key determinant CWP risk. However, experimental to support this link limited. The aim study was assess association between content, and subsequent release bioavailable iron, particles response lung cells involved pathogenesis (epithelial cells, macrophages fibroblasts). Using real-world Australian samples, we found no evidence magnitude detrimental cell response. We did find IL-8 production by epithelial with increasing iron (p = 0.01), however, not linked 0.75) see any positive other types. Given lack cytotoxicity macrophages), inflammatory cytokine fibroblasts), proliferation (fibroblasts) our data do use predictor
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: ['2045-2322']
DOI: https://doi.org/10.1038/s41598-021-87517-z